Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
The Apolipoprotein E e4 Allele and Outcome in Cerebrovascular Disease
Background and Purpose—Polymorphism of the apolipoprotein E gene (APOE) may influence outcome after traumatic brain injury and intracerebral hemorrhage, with the e4 allele being associated with poorer prognosis. We investigated APOE allele distribution in acute stroke and the effect of the e4 allele on outcome. Methods—APOE genotypes were determined in 714 stroke patients: 640 ischemic stroke a...
متن کاملApolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease.
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متن کاملConfirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease.
The Apo E genotype of 86 patients with Alzheimer's disease (AD) and 77 age matched controls was determined by digestion of Apo E PCR products with the restriction enzyme CfoI. The frequency of the e4 allele was significantly increased in the patient group (0.33) as compared with controls (0.12). This effect was seen in patients with a family history and in sporadic cases. The odds ratio in homo...
متن کاملEffect of the Apolipoprotein E e4 Allele on White Matter Hyperintensities in Dementia
Background and Purpose—The clinical significance of the apoE e4 allele in white matter changes in patients with dementia has been a subject of debate. We studied the association between the apoE e4 allele and white matter hyperintensities (WMHs) before and after control for (1) potential vascular risk factors and (2) the presence of lacunar infarcts in patients with dementia. Methods—The subjec...
متن کاملAmyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people.
BACKGROUND The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood. OBJECTIVE To test the hypothesis that amyloid load can account for (mediate) the association of the APOE e4 allele with level of cognition assessed proximate to death. METHODS There were 44 subjects with clinically diagnosed Alzheimer's di...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2004
ISSN: 0022-3050
DOI: 10.1136/jnnp.2003.032276